Hec1/Nek2 Mitotic Pathway Inhibitor INH1 Inhibits the Cell Kinetic Parameters of A549 and HeLa Cells

In this current study, antiproliferative effect of Hec1/Nek2 Mitotic Pathway inhibitor INH1 was investigated in adenocarcinomic human alveolar basal epithelial cells A549 and cervix carcinoma HeLa cell lines vitro. To end index values by xCELLigence Real‐Time Cell Analysis DP instrument, mitotic index, BrdU proliferation assay apoptotic analysis were used. The results the study showed that had cytostatic cytoskeletal effects on cells. IC50 concentration determined as 56 µM with xCelligence device for both lines. used all other parameters. While decreased values, it increased There significant differences between control experimental groups (p<0.05). present suggest may serve a promising treatment option different types cancer.